5udj: Difference between revisions
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==IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA== | |||
<StructureSection load='5udj' size='340' side='right' caption='[[5udj]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5udj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3A:GUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>G3A</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5udi|5udi]], [[5udk|5udk]], [[5udl|5udl]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5udj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udj OCA], [http://pdbe.org/5udj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5udj RCSB], [http://www.ebi.ac.uk/pdbsum/5udj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5udj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN]] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Abbas, Y M]] | |||
[[Category: Damha, M J]] | |||
[[Category: Martinez-Montero, S]] | |||
[[Category: Nagar, B]] | |||
[[Category: Guanosine-triphosphate rna]] | |||
[[Category: Mrna cap]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Tetratricopeptide repeat]] | |||
Revision as of 09:43, 11 March 2017
IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA
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