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| [[Image:1rr8.gif|left|200px]] | | [[Image:1rr8.gif|left|200px]] |
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| {{Structure
| | <!-- |
| |PDB= 1rr8 |SIZE=350|CAPTION= <scene name='initialview01'>1rr8</scene>, resolution 2.6Å
| | The line below this paragraph, containing "STRUCTURE_1rr8", creates the "Structure Box" on the page. |
| |SITE=
| | You may change the PDB parameter (which sets the PDB file loaded into the applet) |
| |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=TTC:(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE'>TTC</scene>, <scene name='pdbligand=TTG:2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC+ACID'>TTG</scene>
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] </span>
| | or leave the SCENE parameter empty for the default display. |
| |GENE= TOP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | | --> |
| |DOMAIN= | | {{STRUCTURE_1rr8| PDB=1rr8 | SCENE= }} |
| |RELATEDENTRY=
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| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rr8 OCA], [http://www.ebi.ac.uk/pdbsum/1rr8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rr8 RCSB]</span>
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| }} | |
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| '''Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I''' | | '''Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I''' |
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| [[Category: Staker, B L.]] | | [[Category: Staker, B L.]] |
| [[Category: Stewart, L.]] | | [[Category: Stewart, L.]] |
| [[Category: camptothecin]] | | [[Category: Camptothecin]] |
| [[Category: human topoisomerase i]] | | [[Category: Human topoisomerase i]] |
| [[Category: nucleic acid]] | | [[Category: Nucleic acid]] |
| [[Category: protein-dna complex]] | | [[Category: Protein-dna complex]] |
| [[Category: topotecan]] | | [[Category: Topotecan]] |
| | | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:48:57 2008'' |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:53 2008'' | |
