4v1x

The structure of the hexameric atrazine chlorohydrolase, AtzA

spinqualitylabelsall models 4v1x, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v1x is a 6 chain structure with sequence from Psesd. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FE, PEG Related: 4v1y Activity: Atrazine chlorohydrolase, with EC number 3.8.1.8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ATZA_PSESD] Hydrolytically dechlorinates atrazine to hydroxyatrazine. Dechlorinates also simazine, and desethylatrazine but is not active with melamine, terbutylazine, or desethyldesisopropylatrazine. Publication Abstract from PubMed Atrazine chlorohydrolase (AtzA) was discovered and purified in the early 1990s from soil that had been exposed to the widely used herbicide atrazine. It was subsequently found that this enzyme catalyzes the first and necessary step in the breakdown of atrazine by the soil organism Pseudomonas sp. strain ADP. Although it has taken 20 years, a crystal structure of the full hexameric form of AtzA has now been obtained. AtzA is less well adapted to its physiological role (i.e. atrazine dechlorination) than the alternative metal-dependent atrazine chlorohydrolase (TrzN), with a substrate-binding pocket that is under considerable strain and for which the substrate is a poor fit. The structure of the hexameric atrazine chlorohydrolase AtzA.,Peat TS, Newman J, Balotra S, Lucent D, Warden AC, Scott C Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):710-20. doi:, 10.1107/S1399004715000619. Epub 2015 Feb 26. PMID:25760618 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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