5ujf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5ujf is ON HOLD~~

==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor==

~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5ujf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJF OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJF FirstGlance].

~~Description:~~ Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </td></tr>

[[Category: ~~Seattle~~ Structural ~~Genomics Center For Infectious Disease (~~Ssgcid)]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ujf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujf OCA], [http://pdbe.org/5ujf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ujf RCSB], [http://www.ebi.ac.uk/pdbsum/5ujf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujf ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

__TOC__

</StructureSection>

[[Category: Dihydrofolate reductase]]

[[Category: Structural genomic]]

[[Category: Dhfr]]

[[Category: Folate]]

[[Category: Oxidoreductase]]

[[Category: P218]]

[[Category: Ssgcid]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ujf is ON HOLD
+==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor==
+<StructureSection load='5ujf' size='340' side='right' caption='[[5ujf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ujf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJF FirstGlance]. <br>
-Description: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ujf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujf OCA], [http://pdbe.org/5ujf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ujf RCSB], [http://www.ebi.ac.uk/pdbsum/5ujf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Structural genomic]]
+[[Category: Dhfr]]
+[[Category: Folate]]
+[[Category: Oxidoreductase]]
+[[Category: P218]]
+[[Category: Ssgcid]]