IGF1: Difference between revisions
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[[Image:IGF1.png|900 px]] | [[Image:IGF1.png|900 px]] | ||
Its 3D structure is : | |||
<Structure load='P05019' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | |||
=== Stimulating interaction : IGF1 - IGF1R === | === Stimulating interaction : IGF1 - IGF1R === | ||
IGF1R is a transmembrane protein receptor. It is composed of two alpha subunits and two tyrosine beta subunits. Both alpha subunits are cysteine-rich region and therefore linked with a disulfide bond. Ligand-binding on alpha subunit induces activation of beta subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. | IGF1R is a transmembrane protein receptor. It is composed of two alpha subunits and two tyrosine beta subunits. Both alpha subunits are cysteine-rich region and therefore linked with a disulfide bond. Ligand-binding on alpha subunit induces activation of beta subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. | ||
