IGF1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 49: | Line 49: | ||
insulin receptor), IGF1 activates a signalling cascade by autocrine or paracrine | insulin receptor), IGF1 activates a signalling cascade by autocrine or paracrine | ||
way resulting in cell growth, proliferation and survival against apoptose. | way resulting in cell growth, proliferation and survival against apoptose. | ||
However IGFBPs can activate or inhibate IGF1 actions on their target cells.<ref></ref> | However IGFBPs can activate or inhibate IGF1 actions on their target cells.<ref>http://www.hal.inserm.fr/tel-00932409/,26/01/2017</ref> <ref>Elena Conti, Maria Beatrice Musumeci, et all, IGF-1 and atherothrombosis: relevance to pathophysiology and therapy,Clinical Science May 01, 2011, 120 (9) 377-402</ref> | ||
If IGF1 is lacking, it reduces cell growth and can also induce dysfunctions or even apoptose of cells, thus creating diseases. | If IGF1 is lacking, it reduces cell growth and can also induce dysfunctions or even apoptose of cells, thus creating diseases. | ||
