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| <StructureSection load='2h7v' size='340' side='right' caption='Human Rac1 (grey) complex with YpkA (pink) and GDP (PDB code [[2h7v]])' scene=''> | | <StructureSection load='2h7v' size='340' side='right' caption='Human Rac1 (grey) complex with YpkA (pink), GDP and Mg+2 ion (green) (PDB code [[2h7v]])' scene=''> |
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| == Function == | | == Function == |
Revision as of 11:17, 12 February 2017
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Function
The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Ras1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes[1]. Ras3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions.
Disease
Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome.
Structural highlights
The interactions between Rac1 and YpkA are via switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA[2].
- ↑ Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013, Feb 15. PMID:23412604 doi:https://dx.doi.org/10.1007/s00125-013-2849-5
- ↑ Prehna G, Ivanov MI, Bliska JB, Stebbins CE. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 2006 Sep 8;126(5):869-80. PMID:16959567 doi:10.1016/j.cell.2006.06.056
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3D structures of Rac
Updated on 12-February-2017
{"openlevels":0}
- Rac1
- Rac1 complex with protein
- 5fi0 – hRac1 + PTDINS (3,4,5)-dependent Rac exchanger
- 4yon – hRac1 (mutant) + PTDINS (3,4,5)-dependent Rac exchanger
- 2yin – hRac1 + dedicator of cytokinesis protein 2
- 3b13 – hRac1 (mutant) + dedicator of cytokinesis protein 2
- 3bji, 2vrw – hRac1 + proto-oncogene VAV
- 2nz8 – hRac1 + triple functional domain protein
- 1foe – hRac1 + TIAM1
- Rac1 complex with protein and nucleotide
- 3ryt – hRac1 (mutant) + plexin-A1 + GNP
- 3su8, 3sua – hRac1 (mutant) + plexin-B1 + GNP
- 2rmk – hRac1 (mutant) + PRK1 + GCP - NMR
- 2fju – hRac1 + phospholipase C beta 2 + GSP
- 2h7v – hRac1 (mutant) + YpkA + GDP
- 1hh4, 1ds6 – hRac1 + RhoGD1 + GDP
- 1i4d, 1i4l – hRac1 + arfaptin + GDP
- 1i4t – hRac1 + arfaptin + GNP
- 1g4u – hRac1 (mutant) + SPTP + GDP
- 1he1 – hRac1 + GTPase-activating protein + GDP
- 1e96 – hRac1 (mutant) + neutrophil cytosol factor 2 + GTP
- Rac2
- 2w2t – hRac2 (mutant) + GDP
- 2w2v – hRac2 (mutant) + GDTP
- 2w2x – hRac2 (mutant) + PLCG2 + GSP
- Rac3
- 2qme – hRac3 + PAK1 + GCP
- 2ov2 – hRac3 + PAK4 + GCP
- 2ic5 – hRac3 + GDP + GNP
- 2g0n, 2c2h – hRac3 + GDP
References
