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[[Image:1sha.gif|left|200px]]
[[Image:1sha.gif|left|200px]]


{{Structure
<!--
|PDB= 1sha |SIZE=350|CAPTION= <scene name='initialview01'>1sha</scene>, resolution 1.5&Aring;
The line below this paragraph, containing "STRUCTURE_1sha", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1sha| PDB=1sha  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sha OCA], [http://www.ebi.ac.uk/pdbsum/1sha PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sha RCSB]</span>
}}


'''CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES'''
'''CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
[[Category: phosphotransferase]]
[[Category: Phosphotransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:42:16 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:00 2008''

Revision as of 05:42, 3 May 2008

File:1sha.gif

Template:STRUCTURE 1sha

CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES


Overview

Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have been determined by X-ray crystallography at resolutions of 1.5 and 2.0 A, respectively. A central antiparallel beta-sheet in the structure is flanked by two alpha-helices, with peptide binding mediated by the sheet, intervening loops and one of the helices. The specific recognition of phosphotyrosine involves amino-aromatic interactions between lysine and arginine side chains and the ring system in addition to hydrogen-bonding interactions with the phosphate.

About this Structure

1SHA is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides., Waksman G, Kominos D, Robertson SC, Pant N, Baltimore D, Birge RB, Cowburn D, Hanafusa H, Mayer BJ, Overduin M, et al., Nature. 1992 Aug 20;358(6388):646-53. PMID:1379696 Page seeded by OCA on Sat May 3 08:42:16 2008

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