5eg6: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==CSL-RITA complex bound to DNA== | |||
<StructureSection load='5eg6' size='340' side='right' caption='[[5eg6]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5eg6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg6 OCA], [http://pdbe.org/5eg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg6 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg6 ProSAT]</span></td></tr> | ||
[[Category: Kovall, R | </table> | ||
[[Category: Tabaja, N | == Function == | ||
[[http://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kovall, R A]] | |||
[[Category: Tabaja, N H]] | |||
[[Category: Notch]] | |||
[[Category: Rbpj]] | |||
[[Category: Transcription-dna binding protein-dna complex]] | |||
