5gk9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5gk9 is ~~ON HOLD until Paper Publication~~

==Crystal structure of human HBO1 in complex with BRPF2==

~~Authors~~: ~~Tao~~, Y., ~~Zhu~~, J., Xu, S., ~~Ding, J~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5gk9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GK9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GK9 FirstGlance].

~~Description~~: ~~Crystal structure~~ of a ~~new HAT complex~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gk9 OCA], [http://pdbe.org/5gk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gk9 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KAT7_HUMAN KAT7_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.<ref>PMID:10438470</ref> <ref>PMID:10930412</ref> <ref>PMID:11278932</ref> <ref>PMID:16387653</ref> <ref>PMID:18832067</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histone acetyltransferase]]

[[Category: Ding, J]]

[[Category: Tao, Y]]

[[Category: Xu, S]]

[[Category: Zhu, J]]

[[Category: ~~Xu, S~~]]

[[Category: Hat]]

[[Category: ~~Tao, Y~~]]

[[Category: Transferase-metal binding protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5gk9 is ON HOLD  until Paper Publication
+==Crystal structure of human HBO1 in complex with BRPF2==
+<StructureSection load='5gk9' size='340' side='right' caption='[[5gk9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Tao, Y., Zhu, J., Xu, S., Ding, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5gk9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GK9 FirstGlance]. <br>
-Description: Crystal structure of a new HAT complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gk9 OCA], [http://pdbe.org/5gk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gk9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KAT7_HUMAN KAT7_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.<ref>PMID:10438470</ref> <ref>PMID:10930412</ref> <ref>PMID:11278932</ref> <ref>PMID:16387653</ref> <ref>PMID:18832067</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone acetyltransferase]]
 [[Category: Ding, J]]
+[[Category: Tao, Y]]
+[[Category: Xu, S]]
 [[Category: Zhu, J]]
-[[Category: Xu, S]]
+[[Category: Hat]]
-[[Category: Tao, Y]]
+[[Category: Transferase-metal binding protein complex]]