5iuq: Difference between revisions

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'''Unreleased structure'''


The entry 5iuq is ON HOLD  until Paper Publication
==Galectin-3c in complex with Bisamido-thiogalactoside derivative 4==
 
<StructureSection load='5iuq' size='340' side='right' caption='[[5iuq]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
Authors: Noresson, A.-L., Aurelius, O., Oberg, C.T., Engstrom, O., Sundin, A.P., Hakansson, M., Logan, D.T., Leffler, H., Nilsson, U.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5iuq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUQ FirstGlance]. <br>
Description: Galectin-3c in complex with Bisamido-thiogalactoside derivative 4
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6E1:3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>6E1</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blj|4blj]], [[4bli|4bli]], [[4bm8|4bm8]]</td></tr>
[[Category: Logan, D.T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuq OCA], [http://pdbe.org/5iuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iuq RCSB], [http://www.ebi.ac.uk/pdbsum/5iuq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuq ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aurelius, O]]
[[Category: Engstrom, O]]
[[Category: Engstrom, O]]
[[Category: Hakansson, M]]
[[Category: Leffler, H]]
[[Category: Leffler, H]]
[[Category: Sundin, A.P]]
[[Category: Logan, D T]]
[[Category: Noresson, A.-L]]
[[Category: Nilsson, U J]]
[[Category: Oberg, C.T]]
[[Category: Noresson, A L]]
[[Category: Nilsson, U.J]]
[[Category: Oberg, C T]]
[[Category: Hakansson, M]]
[[Category: Sundin, A P]]
[[Category: Aurelius, O]]
[[Category: Crd]]
[[Category: Gal3c]]
[[Category: Sugar binding protein]]
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