5jgm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5jgm is ON HOLD until Paper Publication~~

==tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate==

~~Authors: Ehrmann, F.R., Nguyen, D., Heine, A., Klebe, G.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5jgm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JGM FirstGlance].

~~Description:~~ tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=810:ETHYL+[2-(METHYLAMINO)-8-OXO-7,8-DIHYDRO-1H-IMIDAZO[4,5-G]QUINAZOLIN-6-YL]CARBAMATE'>810</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

[[Category: Ehrmann, F.R]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgm OCA], [http://pdbe.org/5jgm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jgm RCSB], [http://www.ebi.ac.uk/pdbsum/5jgm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgm ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

__TOC__

</StructureSection>

[[Category: Ehrmann, F R]]

[[Category: Heine, A]]

[[Category: Klebe, G]]

[[Category: Nguyen, D]]

[[Category: ~~Klebe, G~~]]

[[Category: Co-crystallization]]

[[Category: Prodrug]]

[[Category: Shigellosis]]

[[Category: Transferase]]

[[Category: Transferase inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5jgm is ON HOLD  until Paper Publication
+==tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate==
+<StructureSection load='5jgm' size='340' side='right' caption='[[5jgm]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
-Authors: Ehrmann, F.R., Nguyen, D., Heine, A., Klebe, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jgm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JGM FirstGlance]. <br>
-Description: tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=810:ETHYL+[2-(METHYLAMINO)-8-OXO-7,8-DIHYDRO-1H-IMIDAZO[4,5-G]QUINAZOLIN-6-YL]CARBAMATE'>810</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p0d|1p0d]], [[4puk|4puk]], [[3s1g|3s1g]], [[4kwo|4kwo]], [[5i07|5i07]]</td></tr>
-[[Category: Ehrmann, F.R]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgm OCA], [http://pdbe.org/5jgm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jgm RCSB], [http://www.ebi.ac.uk/pdbsum/5jgm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
+__TOC__
+</StructureSection>
+[[Category: Ehrmann, F R]]
 [[Category: Heine, A]]
+[[Category: Klebe, G]]
 [[Category: Nguyen, D]]
-[[Category: Klebe, G]]
+[[Category: Co-crystallization]]
+[[Category: Prodrug]]
+[[Category: Shigellosis]]
+[[Category: Transferase]]
+[[Category: Transferase inhibitor]]