5jzb: Difference between revisions

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'''Unreleased structure'''


The entry 5jzb is ON HOLD
==Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide==
 
<StructureSection load='5jzb' size='340' side='right' caption='[[5jzb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Ryan, A., Polycarpou, E., Lack, N.A., Evangelopoulos, D., Sieg, C., Halman, A., Bhakta, S., Sinclair, A., Eleftheriadou, O., McHugh, T.D., Keany, S., Lowe, E., Ballet, R., Abihammad, A., Ciulli, A., Sim, E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5jzb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZB FirstGlance]. <br>
Description: Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OT:3,5-DICHLOROBENZENE-1-SULFONAMIDE'>6OT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vf2|2vf2]], [[5jz9|5jz9]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzb OCA], [http://pdbe.org/5jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzb RCSB], [http://www.ebi.ac.uk/pdbsum/5jzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU]] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Abihammad, A]]
[[Category: Ballet, R]]
[[Category: Bhakta, S]]
[[Category: Ciulli, A]]
[[Category: Eleftheriadou, O]]
[[Category: Evangelopoulos, D]]
[[Category: Evangelopoulos, D]]
[[Category: Lack, N.A]]
[[Category: Ryan, A]]
[[Category: Ciulli, A]]
[[Category: Halman, A]]
[[Category: Halman, A]]
[[Category: Keany, S]]
[[Category: Lack, N A]]
[[Category: Lowe, E]]
[[Category: McHugh, T D]]
[[Category: Polycarpou, E]]
[[Category: Polycarpou, E]]
[[Category: Bhakta, S]]
[[Category: Ryan, A]]
[[Category: Sieg, C]]
[[Category: Sieg, C]]
[[Category: Ballet, R]]
[[Category: Keany, S]]
[[Category: Lowe, E]]
[[Category: Abihammad, A]]
[[Category: Eleftheriadou, O]]
[[Category: Sim, E]]
[[Category: Sim, E]]
[[Category: Sinclair, A]]
[[Category: Sinclair, A]]
[[Category: Mchugh, T.D]]
[[Category: Cholesterol]]
[[Category: Hsad]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: M. tuberculosis]]
[[Category: Mcp-hydrolase]]
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