5l6x: Difference between revisions
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==CRYSTAL STRUCTURE OF HGSTP1-1 COMPLEXED WITH FERROCENE-GLUTATHIONE CONJUGATE== | |||
<StructureSection load='5l6x' size='340' side='right' caption='[[5l6x]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L6X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6SG:S-[N-(ferrocenylmethyl)carbamoylmethyl]-glutathione'>6SG</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr> | |||
[[Category: | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSTP1, FAEES3, GST3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l6x OCA], [http://pdbe.org/5l6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l6x RCSB], [http://www.ebi.ac.uk/pdbsum/5l6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l6x ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glutathione transferase]] | |||
[[Category: Human]] | |||
[[Category: Garcia-Fuentes, L]] | |||
[[Category: Lopez-Jaramillo, F J]] | |||
[[Category: Vargas-Berenguel, A]] | [[Category: Vargas-Berenguel, A]] | ||
[[Category: | [[Category: Detoxification]] | ||
[[Category: | [[Category: Ferrocene-glutathione conjugate]] | ||
[[Category: Glutathione s-transferase]] | |||
[[Category: Inhibitor complex]] | |||
[[Category: Transferase]] | |||
Revision as of 10:55, 6 November 2017
CRYSTAL STRUCTURE OF HGSTP1-1 COMPLEXED WITH FERROCENE-GLUTATHIONE CONJUGATE
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