5l76: Difference between revisions
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==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)== | |||
<StructureSection load='5l76' size='340' side='right' caption='[[5l76]], [[Resolution|resolution]] 2.57Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l76]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L76 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l76 OCA], [http://pdbe.org/5l76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l76 RCSB], [http://www.ebi.ac.uk/pdbsum/5l76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l76 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C]] | |||
[[Category: Arruda, P]] | |||
[[Category: Borkowska, O]] | |||
[[Category: Bountra, C]] | |||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
[[Category: Chalk, R]] | [[Category: Chalk, R]] | ||
[[Category: | [[Category: Edwards, A]] | ||
[[Category: | [[Category: Goubin, S]] | ||
[[Category: Kopec, J]] | [[Category: Kopec, J]] | ||
[[Category: Pena, I A]] | |||
[[Category: Rembeza, E]] | |||
[[Category: Pena, I | |||
[[Category: | |||
[[Category: Strain-Damerell, C]] | [[Category: Strain-Damerell, C]] | ||
[[Category: | [[Category: Velupillai, S]] | ||
[[Category: | [[Category: Yue, W W]] | ||
[[Category: Aass]] | |||
[[Category: Aminoadipate semialdehyde synthase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Sdh]] | |||
Revision as of 12:57, 10 May 2017
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)
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