5ltl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ltl is ~~ON HOLD until Paper Publication~~

==Structure of human chemokine CCL16==

~~Authors~~: ~~Weiergraeber~~, O.H., ~~Batra-Safferling~~, R., ~~Haenel~~, K., ~~Willbold~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ltl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LTL FirstGlance]. <br>

~~Description~~: ~~Structure of human chemokine CCL16~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltl OCA], [http://pdbe.org/5ltl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltl RCSB], [http://www.ebi.ac.uk/pdbsum/5ltl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltl ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CCL16_HUMAN CCL16_HUMAN]] Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

__TOC__

</StructureSection>

[[Category: Batra-Safferling, R]]

[[Category: Haenel, K]]

[[Category: Weiergraeber, O H]]

[[Category: Willbold, D]]

[[Category: ~~Haenel, K~~]]

[[Category: Cc-type]]

[[Category: ~~Weiergraeber, O.H~~]]

[[Category: Chemokine]]

[[Category: ~~Batra-Safferling, R~~]]

[[Category: Chemotaxis]]

[[Category: Cytokine]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ltl is ON HOLD  until Paper Publication
+==Structure of human chemokine CCL16==
+<StructureSection load='5ltl' size='340' side='right' caption='[[5ltl]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-Authors: Weiergraeber, O.H., Batra-Safferling, R., Haenel, K., Willbold, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ltl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LTL FirstGlance]. <br>
-Description: Structure of human chemokine CCL16
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltl OCA], [http://pdbe.org/5ltl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltl RCSB], [http://www.ebi.ac.uk/pdbsum/5ltl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CCL16_HUMAN CCL16_HUMAN]] Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
+__TOC__
+</StructureSection>
+[[Category: Batra-Safferling, R]]
+[[Category: Haenel, K]]
+[[Category: Weiergraeber, O H]]
 [[Category: Willbold, D]]
-[[Category: Haenel, K]]
+[[Category: Cc-type]]
-[[Category: Weiergraeber, O.H]]
+[[Category: Chemokine]]
-[[Category: Batra-Safferling, R]]
+[[Category: Chemotaxis]]
+[[Category: Cytokine]]