5m1v: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structures of N-terminal NDM motif of human BLM helicase== | |||
<StructureSection load='5m1v' size='340' side='right' caption='[[5m1v]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5m1v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M1V FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1v OCA], [http://pdbe.org/5m1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1v RCSB], [http://www.ebi.ac.uk/pdbsum/5m1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1v ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: DNA helicase]] | |||
[[Category: Ai, X]] | |||
[[Category: Chen, W F]] | |||
[[Category: Fan, S H]] | |||
[[Category: Liu, N N]] | |||
[[Category: Rety, S]] | [[Category: Rety, S]] | ||
[[Category: Shi, J]] | [[Category: Shi, J]] | ||
[[Category: | [[Category: Xi, X G]] | ||
[[Category: Zhang, B]] | |||
[[Category: Helicase dimerization alpha-helix motif]] | |||
[[Category: Hydrolase]] | |||
Revision as of 06:06, 29 November 2017
Structures of N-terminal NDM motif of human BLM helicase
| ||||||||||||
