5m6b: Difference between revisions
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==structure of recombinant mushroom tyrosinase (abPPO4)== | |||
<StructureSection load='5m6b' size='340' side='right' caption='[[5m6b]], [[Resolution|resolution]] 3.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5m6b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosinase Tyrosinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.1 1.14.18.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6b OCA], [http://pdbe.org/5m6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6b RCSB], [http://www.ebi.ac.uk/pdbsum/5m6b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPO4_AGABI PPO4_AGABI]] Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Tyrosinase]] | |||
[[Category: Bijelic, A]] | |||
[[Category: Pretzler, M]] | [[Category: Pretzler, M]] | ||
[[Category: Rompel, A]] | [[Category: Rompel, A]] | ||
[[Category: Agaricus bisporus]] | |||
[[Category: Heterologous expression]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Polyphenol oxidase]] | |||
[[Category: Tyrosinase activity]] | |||
Revision as of 15:47, 17 May 2017
structure of recombinant mushroom tyrosinase (abPPO4)
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