5mur: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mur is ~~ON HOLD~~

==X-ray structure of the F14'A mutant of GLIC in complex with propofol==

~~Authors~~: ~~Sauguet~~, L., ~~Fourati~~, Z., ~~Delarue~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5mur]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MUR FirstGlance]. <br>

~~Description~~: ~~X-ray structure~~ of the ~~F14'A mutant~~ of ~~GLIC in complex with propofol~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mur OCA], [http://pdbe.org/5mur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mur RCSB], [http://www.ebi.ac.uk/pdbsum/5mur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mur ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Delarue, M]]

[[Category: Fourati, Z]]

~~[[Category: Delarue, M]]~~

[[Category: Sauguet, L]]

[[Category: Membrane protein]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mur is ON HOLD
+==X-ray structure of the F14'A mutant of GLIC in complex with propofol==
+<StructureSection load='5mur' size='340' side='right' caption='[[5mur]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors: Sauguet, L., Fourati, Z., Delarue, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mur]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MUR FirstGlance]. <br>
-Description: X-ray structure of the F14'A mutant of GLIC in complex with propofol
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mur OCA], [http://pdbe.org/5mur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mur RCSB], [http://www.ebi.ac.uk/pdbsum/5mur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mur ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Delarue, M]]
 [[Category: Fourati, Z]]
-[[Category: Delarue, M]]
 [[Category: Sauguet, L]]
+[[Category: Membrane protein]]
+[[Category: Transport protein]]