5mvb: Difference between revisions
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The | ==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand== | ||
<StructureSection load='5mvb' size='340' side='right' caption='[[5mvb]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MVB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [http://pdbe.org/5mvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [http://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Telomeric G-quadruplexes have recently emerged as drug targets in cancer research. Herein, we present the first NMR structure of a telomeric DNA G-quadruplex that adopts the biologically relevant hybrid-2 conformation in a ligand-bound state. We solved the complex with a metalorganic gold(III) ligand that stabilizes G-quadruplexes. Analysis of the free and bound structures reveals structural changes in the capping region of the G-quadruplex. The ligand is sandwiched between one terminal G-tetrad and a flanking nucleotide. This complex structure involves a major structural rearrangement compared to the free G-quadruplex structure as observed for other G-quadruplexes in different conformations, invalidating simple docking approaches to ligand-G-quadruplex structure determination. | |||
Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.,Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grun JT, Papi F, Bazzicalupi C, Messori L, Gratteri P, Schwalbe H Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7102-7106. doi:, 10.1002/anie.201702135. Epub 2017 May 19. PMID:28524432<ref>PMID:28524432</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5mvb" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bazzicalupi, C]] | |||
[[Category: Bendel, L E]] | |||
[[Category: Gratteri, P]] | |||
[[Category: Gruen, T]] | [[Category: Gruen, T]] | ||
[[Category: Jonker, H R.A]] | |||
[[Category: Messori, L]] | [[Category: Messori, L]] | ||
[[Category: Schwalbe, H]] | [[Category: Schwalbe, H]] | ||
[[Category: | [[Category: Wirmer-Bartoschek, J]] | ||
[[Category: | [[Category: Auoxo6]] | ||
[[Category: Dna]] | |||
[[Category: G-quadruplex hybrid]] | |||
Revision as of 09:42, 3 August 2017
Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand
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