5n6f: Difference between revisions
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==Crystal structure of TGT in complex with guanine fragment== | |||
<StructureSection load='5n6f' size='340' side='right' caption='[[5n6f]], [[Resolution|resolution]] 1.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5n6f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6f OCA], [http://pdbe.org/5n6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6f RCSB], [http://www.ebi.ac.uk/pdbsum/5n6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hassaan, E]] | |||
[[Category: Heine, A]] | |||
[[Category: Klebe, G]] | |||
[[Category: Guanine exchange enzyme]] | |||
[[Category: Tgt]] | |||
[[Category: Transferase]] | |||
[[Category: Transglycosylase]] | |||
[[Category: Trna]] | |||
Revision as of 04:58, 8 March 2018
Crystal structure of TGT in complex with guanine fragment
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