5n81: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5n81 ~~is ON HOLD until Paper Publication~~

==Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog==

~~Authors~~: ~~Niquille, D~~.L., ~~Hansen~~, D.A., ~~Mori~~, T., ~~Fercher~~, D., ~~Kries~~, H.~~, Hilvert, D~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5n81]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N81 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N81 FirstGlance].

~~Description: Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=8Q2:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate'>8Q2</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phenylalanine_racemase_(ATP-hydrolyzing) Phenylalanine racemase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.11 5.1.1.11] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n81 OCA], [http://pdbe.org/5n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n81 RCSB], [http://www.ebi.ac.uk/pdbsum/5n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n81 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TYCA_BREPA TYCA_BREPA]] In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer.

__TOC__

</StructureSection>

[[Category: Fercher, D]]

[[Category: ~~Mori~~, T]]

[[Category: Hansen, D A]]

[[Category: Hilvert, D]]

[[Category: Kries, H]]

[[Category: ~~Hansen~~, ~~D.A~~]]

[[Category: Mori, T]]

[[Category: Niquille, D.L]]

[[Category: Niquille, D L]]

[[Category: Adenylation domain]]

[[Category: Ligase]]

[[Category: Nonribosomal peptide synthetase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5n81 is ON HOLD  until Paper Publication
+==Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog==
+<StructureSection load='5n81' size='340' side='right' caption='[[5n81]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Niquille, D.L., Hansen, D.A., Mori, T., Fercher, D., Kries, H., Hilvert, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5n81]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N81 FirstGlance]. <br>
-Description: Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q2:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate'>8Q2</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_racemase_(ATP-hydrolyzing) Phenylalanine racemase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.11 5.1.1.11] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n81 OCA], [http://pdbe.org/5n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n81 RCSB], [http://www.ebi.ac.uk/pdbsum/5n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n81 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TYCA_BREPA TYCA_BREPA]] In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer.
+__TOC__
+</StructureSection>
 [[Category: Fercher, D]]
-[[Category: Mori, T]]
+[[Category: Hansen, D A]]
 [[Category: Hilvert, D]]
 [[Category: Kries, H]]
-[[Category: Hansen, D.A]]
+[[Category: Mori, T]]
-[[Category: Niquille, D.L]]
+[[Category: Niquille, D L]]
+[[Category: Adenylation domain]]
+[[Category: Ligase]]
+[[Category: Nonribosomal peptide synthetase]]