5n8m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5n8m is ~~ON HOLD~~

==Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)==

~~Authors~~: ~~Masliah~~, G., ~~Maris~~, C., ~~Allain~~, H.-~~T.F~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5n8m]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8M FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~TRBP dsRBD~~ 1 ~~and 2~~ in ~~complex with a 19 bp siRNA~~ (~~Complex A~~)

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8m OCA], [http://pdbe.org/5n8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8m RCSB], [http://www.ebi.ac.uk/pdbsum/5n8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8m ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Allain, H T.F]]

[[Category: Maris, C]]

~~[[Category: Allain, H.-T.F]]~~

[[Category: Masliah, G]]

[[Category: Protein-rna complex]]

[[Category: Rna binding protein]]

[[Category: Rnai]]

[[Category: Sirna]]

[[Category: Trbp]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5n8m is ON HOLD
+==Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)==
+<StructureSection load='5n8m' size='340' side='right' caption='[[5n8m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Masliah, G., Maris, C., Allain, H.-T.F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5n8m]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8M FirstGlance]. <br>
-Description: Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8m OCA], [http://pdbe.org/5n8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8m RCSB], [http://www.ebi.ac.uk/pdbsum/5n8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8m ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Allain, H T.F]]
 [[Category: Maris, C]]
-[[Category: Allain, H.-T.F]]
 [[Category: Masliah, G]]
+[[Category: Protein-rna complex]]
+[[Category: Rna binding protein]]
+[[Category: Rnai]]
+[[Category: Sirna]]
+[[Category: Trbp]]