5t44: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5t44 is ~~ON HOLD until Paper Publication~~

==Crystal structure of Frizzled 7 CRD==

~~Authors~~: ~~Nile~~, A.H., ~~Mukund~~, S., ~~Hannous~~, R.H., ~~Wang~~, W.

== Structural highlights ==

<table><tr><td colspan='2'>[[5t44]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T44 FirstGlance]. <br>

~~Description~~: ~~Crystal structure of Frizzled 7 CRD~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t44 OCA], [http://pdbe.org/5t44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t44 RCSB], [http://www.ebi.ac.uk/pdbsum/5t44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t44 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

__TOC__

</StructureSection>

[[Category: Hannous, R H]]

[[Category: Mukund, S]]

[[Category: Nile, A H]]

[[Category: Stanger, K]]

[[Category: Wang, W]]

[[Category: ~~Nile, A.H~~]]

[[Category: Cysteine rich domain]]

[[Category: ~~Hannous, R.H]]~~

[[Category: Immune system]]

~~[[Category: Mukund, S~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5t44 is ON HOLD  until Paper Publication
+==Crystal structure of Frizzled 7 CRD==
+<StructureSection load='5t44' size='340' side='right' caption='[[5t44]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
-Authors: Nile, A.H., Mukund, S., Hannous, R.H., Wang, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t44]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T44 FirstGlance]. <br>
-Description: Crystal structure of Frizzled 7 CRD
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t44 OCA], [http://pdbe.org/5t44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t44 RCSB], [http://www.ebi.ac.uk/pdbsum/5t44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t44 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
+__TOC__
+</StructureSection>
+[[Category: Hannous, R H]]
+[[Category: Mukund, S]]
+[[Category: Nile, A H]]
+[[Category: Stanger, K]]
 [[Category: Wang, W]]
-[[Category: Nile, A.H]]
+[[Category: Cysteine rich domain]]
-[[Category: Hannous, R.H]]
+[[Category: Immune system]]
-[[Category: Mukund, S]]