5tbx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5tbx is ~~ON HOLD until Paper Publication~~

==hnRNP A18 RNA Recognition Motif==

~~Authors~~: ~~Coburn~~, K.M., ~~Melville, Z~~., ~~Aligholizadeh, E~~.~~, Roth, B~~.M., ~~Varney, K~~.M., ~~Weber, D~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TBX FirstGlance]. <br>

~~Description~~: ~~hnRNP A18 RNA Recognition Motif~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [http://pdbe.org/5tbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [http://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr>

[[Category: ~~Roth~~, B.M]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN]] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Aligholizadeh, E]]

[[Category: Coburn, K M]]

[[Category: Melville, Z]]

[[Category: ~~Coburn~~, K.M]]

[[Category: Roth, B M]]

[[Category: Varney, K.M]]

[[Category: Varney, K M]]

[[Category: Weber, D.J]]

[[Category: Weber, D J]]

[[Category: ~~Aligholizadeh, E~~]]

[[Category: Rna binding protein]]

[[Category: Rna-binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5tbx is ON HOLD  until Paper Publication
+==hnRNP A18 RNA Recognition Motif==
+<StructureSection load='5tbx' size='340' side='right' caption='[[5tbx]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-Authors: Coburn, K.M., Melville, Z., Aligholizadeh, E., Roth, B.M., Varney, K.M., Weber, D.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TBX FirstGlance]. <br>
-Description: hnRNP A18 RNA Recognition Motif
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [http://pdbe.org/5tbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [http://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr>
-[[Category: Roth, B.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN]] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aligholizadeh, E]]
+[[Category: Coburn, K M]]
 [[Category: Melville, Z]]
-[[Category: Coburn, K.M]]
+[[Category: Roth, B M]]
-[[Category: Varney, K.M]]
+[[Category: Varney, K M]]
-[[Category: Weber, D.J]]
+[[Category: Weber, D J]]
-[[Category: Aligholizadeh, E]]
+[[Category: Rna binding protein]]
+[[Category: Rna-binding protein]]