5u6v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5u6v is ~~ON HOLD~~ ~~until Paper Publication~~

==X-ray crystal structure of 1,2,3-triazolobenzodiazepine in complex with BRD2(D2)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5u6v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U6V FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7WY:5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine'>7WY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u6v OCA], [http://pdbe.org/5u6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u6v RCSB], [http://www.ebi.ac.uk/pdbsum/5u6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u6v ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Burns, C J]]

[[Category: Czabotar, P E]]

[[Category: Garnier, J M]]

[[Category: Hatfaludi, T]]

[[Category: Sharp, P P]]

[[Category: Benzodiazepine]]

[[Category: Bromodomain]]

[[Category: Epigenetic]]

[[Category: Transcription-transcription inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5u6v is ON HOLD  until Paper Publication
+==X-ray crystal structure of 1,2,3-triazolobenzodiazepine in complex with BRD2(D2)==
+<StructureSection load='5u6v' size='340' side='right' caption='[[5u6v]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5u6v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U6V FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7WY:5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine'>7WY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u6v OCA], [http://pdbe.org/5u6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u6v RCSB], [http://www.ebi.ac.uk/pdbsum/5u6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u6v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Burns, C J]]
+[[Category: Czabotar, P E]]
+[[Category: Garnier, J M]]
+[[Category: Hatfaludi, T]]
+[[Category: Sharp, P P]]
+[[Category: Benzodiazepine]]
+[[Category: Bromodomain]]
+[[Category: Epigenetic]]
+[[Category: Transcription-transcription inhibitor complex]]