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==NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y== | |||
<StructureSection load='5ug5' size='340' side='right' caption='[[5ug5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ug5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UG5 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ug3|5ug3]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ug5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ug5 OCA], [http://pdbe.org/5ug5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ug5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ug5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ug5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CA1D_CONGE CA1D_CONGE]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin reversibly blocks alpha-3-beta-2 (IC(50)=3.1-5.1 nM), alpha-7 (IC(50)=4.5-5.1 nM), and alpha-4-beta-2 (IC(50)=128.6-390 nM) nAChRs.<ref>PMID:12419800</ref> <ref>PMID:15929983</ref> <ref>PMID:19098004</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bonneau, R]] | |||
[[Category: Filipenko, P]] | |||
[[Category: Gorson, J]] | |||
[[Category: Heizmann, A]] | |||
[[Category: Holford, M]] | |||
[[Category: Hussein, A]] | |||
[[Category: Kuryatov, A]] | |||
[[Category: Leffler, A E]] | |||
[[Category: Lindstrom, J]] | |||
[[Category: Lyskov, S]] | |||
[[Category: Nicke, A]] | |||
[[Category: Poget, S F]] | |||
[[Category: Powell, S R]] | |||
[[Category: Rudy, B]] | |||
[[Category: Zebroski, H A]] | |||
[[Category: Neurotoxin]] | |||
[[Category: Toxin]] | |||
Revision as of 09:41, 13 September 2017
NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y
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