5un6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 5un6~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5un6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5un5|5un5]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un6 OCA], [http://pdbe.org/5un6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un6 RCSB], [http://www.ebi.ac.uk/pdbsum/5un6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un6 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FZD8_HUMAN FZD8_HUMAN]] Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.<ref>PMID:11448771</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Garcia, K C]]

[[Category: Janda, C Y]]

[[Category: Jude, K M]]

[[Category: Signaling protein-de novo protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5un6 is ON HOLD  until Paper Publication
+==Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset==
+<StructureSection load='5un6' size='340' side='right' caption='[[5un6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5un6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5un5|5un5]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un6 OCA], [http://pdbe.org/5un6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un6 RCSB], [http://www.ebi.ac.uk/pdbsum/5un6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FZD8_HUMAN FZD8_HUMAN]] Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.<ref>PMID:11448771</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Garcia, K C]]
+[[Category: Janda, C Y]]
+[[Category: Jude, K M]]
+[[Category: Signaling protein-de novo protein complex]]