5un9: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 5un9 is ON HOLD until Paper Publication~~

==The crystal structure of human O-GlcNAcase in complex with Thiamet-G==

~~Authors: Li, B., Jiang, J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5un9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN9 FirstGlance].

~~Description:~~ The crystal structure of human O-GlcNAcase in complex with Thiamet-G

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NHT:(3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NHT</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5un8|5un8]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un9 OCA], [http://pdbe.org/5un9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un9 RCSB], [http://www.ebi.ac.uk/pdbsum/5un9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un9 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Jiang, J]]

[[Category: Li, B]]

[[Category: Human o-glcnacase]]

[[Category: Hydrolase]]

[[Category: Thiemat-g]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5un9 is ON HOLD  until Paper Publication
+==The crystal structure of human O-GlcNAcase in complex with Thiamet-G==
+<StructureSection load='5un9' size='340' side='right' caption='[[5un9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Li, B., Jiang, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5un9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN9 FirstGlance]. <br>
-Description: The crystal structure of human O-GlcNAcase in complex with Thiamet-G
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHT:(3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NHT</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5un8|5un8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un9 OCA], [http://pdbe.org/5un9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un9 RCSB], [http://www.ebi.ac.uk/pdbsum/5un9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref>   Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Jiang, J]]
 [[Category: Li, B]]
+[[Category: Human o-glcnacase]]
+[[Category: Hydrolase]]
+[[Category: Thiemat-g]]