1t2s: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1t2s.gif|left|200px]]
[[Image:1t2s.gif|left|200px]]


{{Structure
<!--
|PDB= 1t2s |SIZE=350|CAPTION= <scene name='initialview01'>1t2s</scene>
The line below this paragraph, containing "STRUCTURE_1t2s", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=
-->
|DOMAIN=
{{STRUCTURE_1t2s| PDB=1t2s | SCENE= }}  
|RELATEDENTRY=[[1t2s|1T2S]], [[1upo|1UPO]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2s OCA], [http://www.ebi.ac.uk/pdbsum/1t2s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2s RCSB]</span>
}}


'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
Line 29: Line 26:
[[Category: Sattler, M.]]
[[Category: Sattler, M.]]
[[Category: Simon, B.]]
[[Category: Simon, B.]]
[[Category: dna]]
[[Category: Dna]]
[[Category: nucleic acid binding protein]]
[[Category: Nucleic acid binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:26:37 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:26 2008''

Revision as of 06:26, 3 May 2008

File:1t2s.gif

Template:STRUCTURE 1t2s

Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain


Overview

We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

About this Structure

1T2S is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196 Page seeded by OCA on Sat May 3 09:26:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1t2s&oldid=420214"