5wy0: Difference between revisions
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==Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet== | |||
<StructureSection load='5wy0' size='340' side='right' caption='[[5wy0]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5wy0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WY0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy0 OCA], [http://pdbe.org/5wy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy0 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN]] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Huang, Y]] | |||
[[Category: Ma, J B]] | |||
[[Category: Peng, L]] | |||
[[Category: Wu, L G]] | |||
[[Category: Adomet]] | |||
[[Category: Rna methyltranferase]] | |||
[[Category: Transferase]] | |||
Revision as of 06:56, 17 January 2018
Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet
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