4qho: Difference between revisions
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==Crystal structure of an oxygenase in complex with inhibitor cco010== | ==Crystal structure of an oxygenase in complex with inhibitor cco010== | ||
<StructureSection load='4qho' size='340' side='right' caption='[[4qho]], [[Resolution|resolution]] 2.37Å' scene=''> | <StructureSection load='4qho' size='340' side='right'caption='[[4qho]], [[Resolution|resolution]] 2.37Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qho]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHO FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NKG:N-{[3-HYDROXY-6-(NAPHTHALEN-1-YL)PYRIDIN-2-YL]CARBONYL}GLYCINE'>NKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NKG:N-{[3-HYDROXY-6-(NAPHTHALEN-1-YL)PYRIDIN-2-YL]CARBONYL}GLYCINE'>NKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lfm|3lfm]], [[4idz|4idz]], [[4ie0|4ie0]], [[4ie4|4ie4]], [[4ie5|4ie5]], [[4ie6|4ie6]], [[4ie7|4ie7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lfm|3lfm]], [[4idz|4idz]], [[4ie0|4ie0]], [[4ie4|4ie4]], [[4ie5|4ie5]], [[4ie6|4ie6]], [[4ie7|4ie7]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FTO, KIAA1752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qho OCA], [http://pdbe.org/4qho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qho RCSB], [http://www.ebi.ac.uk/pdbsum/4qho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qho ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qho OCA], [http://pdbe.org/4qho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qho RCSB], [http://www.ebi.ac.uk/pdbsum/4qho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qho ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | [[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | ||
==See Also== | |||
*[[Dioxygenase|Dioxygenase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Aik, W S]] | [[Category: Aik, W S]] | ||
[[Category: Connor, C Clunie-O]] | [[Category: Connor, C Clunie-O]] | ||
