4z0k: Difference between revisions
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==Rapid development of two Factor IXa inhibitors from Hit to Lead== | ==Rapid development of two Factor IXa inhibitors from Hit to Lead== | ||
<StructureSection load='4z0k' size='340' side='right' caption='[[4z0k]], [[Resolution|resolution]] 1.41Å' scene=''> | <StructureSection load='4z0k' size='340' side='right'caption='[[4z0k]], [[Resolution|resolution]] 1.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4z0k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0K FirstGlance]. <br> | <table><tr><td colspan='2'>[[4z0k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0K FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LN:N-[(2R)-10-HYDROXY-2,7-DIMETHYL-1,2,3,4-TETRAHYDROPYRIDO[1,2-B]INDAZOL-2-YL]-4-(4H-1,2,4-TRIAZOL-4-YL)BENZAMIDE'>4LN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LN:N-[(2R)-10-HYDROXY-2,7-DIMETHYL-1,2,3,4-TETRAHYDROPYRIDO[1,2-B]INDAZOL-2-YL]-4-(4H-1,2,4-TRIAZOL-4-YL)BENZAMIDE'>4LN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yzu|4yzu]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yzu|4yzu]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_IXa Coagulation factor IXa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.22 3.4.21.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_IXa Coagulation factor IXa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.22 3.4.21.22] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0k OCA], [http://pdbe.org/4z0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0k RCSB], [http://www.ebi.ac.uk/pdbsum/4z0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0k OCA], [http://pdbe.org/4z0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0k RCSB], [http://www.ebi.ac.uk/pdbsum/4z0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0k ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4z0k" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4z0k" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Factor IX|Factor IX]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Coagulation factor IXa]] | [[Category: Coagulation factor IXa]] | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Hruza, A]] | [[Category: Hruza, A]] | ||
[[Category: Reichert, P]] | [[Category: Reichert, P]] | ||
