1tf2: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1tf2.jpg|left|200px]] | [[Image:1tf2.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1tf2", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1tf2| PDB=1tf2 | SCENE= }} | |||
}} | |||
'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis''' | '''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis''' | ||
| Line 28: | Line 25: | ||
[[Category: Osborne, A R.]] | [[Category: Osborne, A R.]] | ||
[[Category: Rapoport, T A.]] | [[Category: Rapoport, T A.]] | ||
[[Category: | [[Category: Atpase]] | ||
[[Category: | [[Category: Helicase]] | ||
[[Category: | [[Category: Secretion]] | ||
[[Category: | [[Category: Translocation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:52:27 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 06:52, 3 May 2008
Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis
Overview
The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
About this Structure
1TF2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:15256599 Page seeded by OCA on Sat May 3 09:52:27 2008
