Sandbox Reserved 1061: Difference between revisions

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=== Active State ===

Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.

Originally it was thought to be cleaved and activated by a combination of Caspases-3 and -7, but research has shown that Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.

<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene>~~Text To Be Displayed</scene>~~[[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]

<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene> this shows the protein bound [[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]

== Mechanism of Action ==

Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174. It is tightly regulated by Zinc binding to an allosteric site.

== Zinc Ligand(s) ==

The Zinc ligand is known to inhibit the

The Zinc ligand is known to inhibit the Caspase-6 protein.

== Other Ligands ==

Other ligands that bind to Caspase-6 are caspase-8, which is activated within the caspase-chain by Caspase 6. After it being activated by Caspase-6, Caspase-8 is then in it's active state. Caspase-6 has been know to be a self-activator, so other Caspase-6 proteins are also known to be ligands that are bound at the active site.

Sandbox Reserved 1061: Difference between revisions

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@@ Line 17: / Line 17: @@
 === Active State ===
-Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.
+Originally it was thought to be cleaved and activated by a combination of Caspases-3 and -7, but research has shown that Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.
-<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene>Text To Be Displayed</scene>[[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]
+<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene> this shows the protein bound [[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]
 == Mechanism of Action ==
 Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174. It is tightly regulated by Zinc binding to an allosteric site.
 == Zinc Ligand(s) ==
-The Zinc ligand is known to inhibit the
+The Zinc ligand is known to inhibit the Caspase-6 protein.
 == Other Ligands ==
 Other ligands that bind to Caspase-6 are caspase-8, which is activated within the caspase-chain by Caspase 6. After it being activated by Caspase-6, Caspase-8 is then in it's active state. Caspase-6 has been know to be a self-activator, so other Caspase-6 proteins are also known to be ligands that are bound at the active site.