5naf: Difference between revisions
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==Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain== | |||
<StructureSection load='5naf' size='340' side='right' caption='[[5naf]], [[Resolution|resolution]] 2.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5naf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NAF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5naf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5naf OCA], [http://pdbe.org/5naf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5naf RCSB], [http://www.ebi.ac.uk/pdbsum/5naf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5naf ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TBL1R_MOUSE TBL1R_MOUSE]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). [[http://www.uniprot.org/uniprot/MECP2_MOUSE MECP2_MOUSE]] Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).<ref>PMID:23434322</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cook, A G]] | |||
[[Category: Kruusvee, V]] | [[Category: Kruusvee, V]] | ||
[[Category: | [[Category: Protein-peptide complex]] | ||
[[Category: Rett syndrome]] | |||
[[Category: Transcription]] | |||
[[Category: Transcriptional repressor]] | |||
[[Category: Wd40 domain]] | |||
Revision as of 13:48, 29 March 2017
Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain
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