5nbt: Difference between revisions
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==Apo structure of p60N/p80C katanin== | |||
<StructureSection load='5nbt' size='340' side='right' caption='[[5nbt]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nbt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NBT FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Microtubule-severing_ATPase Microtubule-severing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.3 3.6.4.3] </span></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nbt OCA], [http://pdbe.org/5nbt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nbt RCSB], [http://www.ebi.ac.uk/pdbsum/5nbt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nbt ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KTNB1_MOUSE KTNB1_MOUSE]] Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.[HAMAP-Rule:MF_03022] [[http://www.uniprot.org/uniprot/KTNA1_MOUSE KTNA1_MOUSE]] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity).[HAMAP-Rule:MF_03023] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Microtubule-severing ATPase]] | |||
[[Category: Akhmanova, A]] | [[Category: Akhmanova, A]] | ||
[[Category: Altelaar, A F.M]] | |||
[[Category: Capitani, G]] | |||
[[Category: Heck, A J.R]] | |||
[[Category: Hua, S]] | [[Category: Hua, S]] | ||
[[Category: | [[Category: Jiang, K]] | ||
[[Category: Kammerer, R A]] | |||
[[Category: Kammerer, R | [[Category: Liu, Q]] | ||
[[Category: | |||
[[Category: Rezabkova, L]] | [[Category: Rezabkova, L]] | ||
[[Category: Steinmetz, M | [[Category: Steinmetz, M O]] | ||
[[Category: | [[Category: Cytoskeleton]] | ||
[[Category: Hydrolase]] | |||
[[Category: Katanin]] | |||
[[Category: Microtubule]] | |||
[[Category: Severing enzyme]] | |||
