5ubb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ubb is ~~ON HOLD~~

==Crystal structure of human alpha N-terminal protein methyltransferase 1B==

~~Authors~~: ~~Dong~~, C., ~~Zhu, L~~.~~, Tempel, W~~., ~~Dong, A~~., ~~Bountra, C~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Min, J~~.~~, Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBB FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human alpha~~ N-terminal ~~protein methyltransferase 1B~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Protein_N-terminal_monomethyltransferase Protein N-terminal monomethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.299 2.1.1.299] </td></tr>

[[Category: Arrowsmith, C.H]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubb OCA], [http://pdbe.org/5ubb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubb RCSB], [http://www.ebi.ac.uk/pdbsum/5ubb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubb ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NTM1B_HUMAN NTM1B_HUMAN]] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.<ref>PMID:24090352</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Protein N-terminal monomethyltransferase]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Dong, A]]

[[Category: Dong, C]]

[[Category: Edwards, A M]]

[[Category: Min, J]]

~~[[Category: Edwards, A.M]]~~

[[Category: Structural genomic]]

[[Category: Structural ~~Genomics Consortium (Sgc)]]~~

~~[[Category: Bountra, C~~]]

[[Category: Tempel, W]]

[[Category: Zhu, L]]

[[Category: Methyl transferase]]

[[Category: Sgc]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ubb is ON HOLD
+==Crystal structure of human alpha N-terminal protein methyltransferase 1B==
+<StructureSection load='5ubb' size='340' side='right' caption='[[5ubb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Dong, C., Zhu, L., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBB FirstGlance]. <br>
-Description: Crystal structure of human alpha N-terminal protein methyltransferase 1B
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_N-terminal_monomethyltransferase Protein N-terminal monomethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.299 2.1.1.299] </span></td></tr>
-[[Category: Arrowsmith, C.H]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubb OCA], [http://pdbe.org/5ubb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubb RCSB], [http://www.ebi.ac.uk/pdbsum/5ubb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NTM1B_HUMAN NTM1B_HUMAN]] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.<ref>PMID:24090352</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Protein N-terminal monomethyltransferase]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
 [[Category: Dong, A]]
 [[Category: Dong, C]]
+[[Category: Edwards, A M]]
 [[Category: Min, J]]
-[[Category: Edwards, A.M]]
+[[Category: Structural genomic]]
-[[Category: Structural Genomics Consortium (Sgc)]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
 [[Category: Zhu, L]]
+[[Category: Methyl transferase]]
+[[Category: Sgc]]
+[[Category: Transferase]]