1tou: Difference between revisions
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand''' | '''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand''' | ||
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[[Category: Rondahl, L.]] | [[Category: Rondahl, L.]] | ||
[[Category: Uppenberg, J.]] | [[Category: Uppenberg, J.]] | ||
[[Category: | [[Category: Lipid-binding]] | ||
[[Category: | [[Category: Transport]] | ||
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Revision as of 07:12, 3 May 2008
Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand
Overview
The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
About this Structure
1TOU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970 Page seeded by OCA on Sat May 3 10:12:01 2008
