Sandbox1996: Difference between revisions
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== Medical Applications and Relevance == | == Medical Applications and Relevance == | ||
'''Hypertension''' | '''Hypertension''' | ||
Although Diuril was introduced as an anti-diuretic drug, its antihypertensive properties were discovered when two researchers from Boston and Washington D.C administered the drug to patients suffering from congestive heart failure, edema and severe hypertension, and noted a dramatic reduction in high blood pressure. Unlike other hypotensive drugs, that lowers blood pressure equally in both hypertensive and normotensive patients, Diuril reduces the blood pressure of patients in the hypertensive state only. It therefore possesses considerable specificity. Diuril was also favored over other hypotensive drugs because of its ease of administration; it was delivered orally and required no hospitalization, nor testing to monitor immediate adverse effects. When combined with agents such as ganglionic blockers, reserpine, and hydralazine, its efficacy was synergistically increased while minimizing its respective toxicities. | Although Diuril was introduced as an anti-diuretic drug, its antihypertensive properties were discovered when two researchers from Boston and Washington D.C administered the drug to patients suffering from congestive heart failure, edema and severe hypertension, and noted a dramatic reduction in high blood pressure. Unlike other hypotensive drugs, that lowers blood pressure equally in both hypertensive and normotensive patients, Diuril reduces the blood pressure of patients in the hypertensive state only. It therefore possesses considerable specificity. Diuril was also favored over other hypotensive drugs because of its ease of administration; it was delivered orally and required no hospitalization, nor testing to monitor immediate adverse effects. When combined with agents such as ganglionic blockers, reserpine, and hydralazine, its efficacy was synergistically increased while minimizing its respective toxicities. | ||
