5nfj: Difference between revisions

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'''Unreleased structure'''


The entry 5nfj is ON HOLD until Paper Publication
==Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)==
 
<StructureSection load='5nfj' size='340' side='right' caption='[[5nfj]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5nfj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NFJ FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfj OCA], [http://pdbe.org/5nfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfj RCSB], [http://www.ebi.ac.uk/pdbsum/5nfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfj ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TM10C_HUMAN TM10C_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/TM10C_HUMAN TM10C_HUMAN]] Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297).<ref>PMID:18984158</ref> <ref>PMID:21593607</ref> <ref>PMID:23042678</ref> <ref>PMID:27132592</ref> <ref>PMID:29040705</ref> <ref>PMID:29072297</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Chalk, R]]
[[Category: Delft, F von]]
[[Category: Edwards, C]]
[[Category: Fairhead, M]]
[[Category: Fitzpatrick, F]]
[[Category: Kopec, J]]
[[Category: Newman, J A]]
[[Category: Oerum, S]]
[[Category: Oppermann, U]]
[[Category: Structural genomic]]
[[Category: Shrestha, L]]
[[Category: Talon, R]]
[[Category: Yue, W W]]
[[Category: Methylation]]
[[Category: Sgc]]
[[Category: Spout]]
[[Category: Transferase]]
[[Category: Trmt10c]]
[[Category: Trna]]
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