5v52: Difference between revisions
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==Structure of TIGIT bound to nectin-2 (CD112)== | |||
<StructureSection load='5v52' size='340' side='right' caption='[[5v52]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5v52]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V52 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v52 OCA], [http://pdbe.org/5v52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v52 RCSB], [http://www.ebi.ac.uk/pdbsum/5v52 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v52 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. [[http://www.uniprot.org/uniprot/NECT2_HUMAN NECT2_HUMAN]] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).<ref>PMID:26755705</ref> <ref>PMID:9657005</ref> (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).<ref>PMID:11602758</ref> <ref>PMID:9657005</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Berry, R]] | |||
[[Category: Deuss, F A]] | |||
[[Category: Gully, B S]] | |||
[[Category: Rossjohn, J]] | |||
[[Category: Adhesion molecule]] | |||
[[Category: Immune receptor]] | |||
[[Category: Immune system]] | |||
[[Category: Immunoglobulin fold]] | |||
Revision as of 13:51, 24 May 2017
Structure of TIGIT bound to nectin-2 (CD112)
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