5nkp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
m Protected "5nkp" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5nkp is ON HOLD
==Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide==
 
<StructureSection load='5nkp' size='340' side='right' caption='[[5nkp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Chen, Z., Sorrell, F.J., Pinkas, D.M., Williams, E., Mathea, S., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5nkp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NKP FirstGlance]. <br>
Description: Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch9|4ch9]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nkp OCA], [http://pdbe.org/5nkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nkp RCSB], [http://www.ebi.ac.uk/pdbsum/5nkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nkp ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN]] Pseudohypoaldosteronism type 2D. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN]] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.<ref>PMID:14528312</ref> <ref>PMID:23387299</ref> <ref>PMID:23453970</ref> <ref>PMID:23665031</ref> <ref>PMID:23576762</ref> <ref>PMID:22406640</ref>  [[http://www.uniprot.org/uniprot/WNK3_HUMAN WNK3_HUMAN]] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.<ref>PMID:16275911</ref> <ref>PMID:16275913</ref> <ref>PMID:16357011</ref> <ref>PMID:16501604</ref> <ref>PMID:17975670</ref> <ref>PMID:18768590</ref> <ref>PMID:20525693</ref>  Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.<ref>PMID:19470686</ref> <ref>PMID:21613606</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bullock, A]]
[[Category: Bullock, A]]
[[Category: Burgess-Brown, N]]
[[Category: Chen, Z]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Goubin, S]]
[[Category: Goubin, S]]
[[Category: Mathea, S]]
[[Category: Mathea, S]]
[[Category: Arrowsmith, C.H]]
[[Category: Pinkas, D M]]
[[Category: Sorrell, F J]]
[[Category: Williams, E]]
[[Category: Williams, E]]
[[Category: Von Delft, F]]
[[Category: Kelch domain]]
[[Category: Pinkas, D.M]]
[[Category: Transferase]]
[[Category: Edwards, A.M]]
[[Category: Chen, Z]]
[[Category: Bountra, C]]
[[Category: Sorrell, F.J]]
Retrieved from "https://proteopedia.org/5nkp"