5nmf: Difference between revisions

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'''Unreleased structure'''


The entry 5nmf is ON HOLD
==868 TCR in complex with HLA A02 presenting SLYNTIATL==
 
<StructureSection load='5nmf' size='340' side='right' caption='[[5nmf]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
Authors: Rizkallah, P.J., Cole, D.K., Fuller, A., Sewell, A.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5nmf]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NMF FirstGlance]. <br>
Description: TCR
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nmf OCA], [http://pdbe.org/5nmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nmf RCSB], [http://www.ebi.ac.uk/pdbsum/5nmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nmf ProSAT]</span></td></tr>
[[Category: Sewell, A.K]]
</table>
[[Category: Rizkallah, P.J]]
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cole, D K]]
[[Category: Fuller, A]]
[[Category: Fuller, A]]
[[Category: Cole, D.K]]
[[Category: Rizkallah, P J]]
[[Category: Sewell, A K]]
[[Category: Cd8+]]
[[Category: Immune system]]
[[Category: Mhc]]
[[Category: Tcr]]
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