Sandbox GGC2

Glucokinase

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Glucokinase is also known as human hexokinase IV. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate. This is a default text for your page Sandbox GGC2. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Structure Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a small domain and a large domain. When glucose molecule binds to the active site of glucoskinase, it forms hydrogen bonds with Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI)will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site. Function active site(yellow)and allosteric site (dark blue) Structural highlights ^_^ cartoon - Glucokinase without ligand This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.