Transketolase

spinqualitylabelsall models E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code 2r8o). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Transketolase (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle. Structural highlights The active site of TKT contains a ligand-cofactor adduct.

3D Structures of transketolase

Updated on 19-April-2017

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• Transketolase
  • 1trk – yTKT – yeast
  • 1ay0 – yTKT (mutant)
  • 2e6k – TKT – Thermus thermophilus
  • 3hyl – BaTKT – Bacillus anthracis
  • 3kom – TKT (mutant) – Francisella tularensis
  • 3l84 – CjTKT – Campylobacter jejuni
    
  • 3rim – TKT – Mycobacterium tuberculosis
    
  • 3uk1 – BtTKT – Burkholderia thailandensis
    
  • 4c7v - LsTKT – Lactobacillus salivarius
    
  • 4xeu - TKT – Pseudomonas aeruginosa
    
• Transketolase binary complexes
  • 3m49 – BaTKT + TPP
  • 3mos, 3ooy – hTKT + TPP - human
    
  • 4kxy - hTKT + TPP analog
    
  • 1tka, 1tkb, 1tkc – yTKT + TPP analog
  • 1gpu - yTKT 1 + TPP derivative
  • 1itz - TKT + TPP – maize
  • 1qgd - EcTKT + TPP – Escherichia coli
  • 1r9j - TKT + TPP – Leishmania mexicana
    
  • 4c7x - LsTKT + TPP
    
• Transketolase ternary complexes
  • 3m7i, 3m6l – CjTKT + TPP + ribose 5-P
  • 3m34 - CjTKT + TPP + Ca
  • 1ngs - yTKT + TPP + Ca + erythrose-4-P
  • 2r5n – EcTKT 1 + TPP + ribose 5-P
    
  • 3upt - BtTKT + TPP + ribose 5-P
    
  • 2r8o - EcTKT 1 + TPP + xylulose 5-P
  • 2r8p - EcTKT 1 + TPP + fructose 6-P
    
  • 4kxu - hTKT + TPP + sorbitol 6-P
    
  • 4kxv, 4kxw - hTKT + TPP + xylitol 5-P
    
  • 4kxx - hTKT + TPP + seduheptulose 7-P
    

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