5no6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5no6 is ~~ON HOLD until Paper Publication~~

==TEAD4-HOXB13 complex bound to DNA==

~~Authors~~: ~~Morgunova~~, E., ~~Jolma~~, A., ~~Yin~~, Y., ~~Popov~~, A., ~~Taipale~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5no6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NO6 FirstGlance]. <br>

~~Description~~: ~~TEAD4-HOXB13 complex bound to DNA~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5no6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5no6 OCA], [http://pdbe.org/5no6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5no6 RCSB], [http://www.ebi.ac.uk/pdbsum/5no6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5no6 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TEAD4_HUMAN TEAD4_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref> [[http://www.uniprot.org/uniprot/HXB13_HUMAN HXB13_HUMAN]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

== References ==

__TOC__

</StructureSection>

[[Category: Jolma, A]]

[[Category: Morgunova, E]]

[[Category: Popov, A]]

[[Category: Taipale, J]]

[[Category: Yin, Y]]

[[Category: ~~Jolma, A~~]]

[[Category: Dna binding]]

[[Category: ~~Taipale, J~~]]

[[Category: Transcription]]

[[Category: ~~Morgunova, E~~]]

[[Category: Transcription factor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5no6 is ON HOLD  until Paper Publication
+==TEAD4-HOXB13 complex bound to DNA==
+<StructureSection load='5no6' size='340' side='right' caption='[[5no6]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5no6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NO6 FirstGlance]. <br>
-Description: TEAD4-HOXB13 complex bound to DNA
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5no6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5no6 OCA], [http://pdbe.org/5no6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5no6 RCSB], [http://www.ebi.ac.uk/pdbsum/5no6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5no6 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TEAD4_HUMAN TEAD4_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>  [[http://www.uniprot.org/uniprot/HXB13_HUMAN HXB13_HUMAN]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Jolma, A]]
+[[Category: Morgunova, E]]
 [[Category: Popov, A]]
+[[Category: Taipale, J]]
 [[Category: Yin, Y]]
-[[Category: Jolma, A]]
+[[Category: Dna binding]]
-[[Category: Taipale, J]]
+[[Category: Transcription]]
-[[Category: Morgunova, E]]
+[[Category: Transcription factor]]