Sandbox1996: Difference between revisions

==Diuril (Chlorothiazide)==

<scene name='75/756546/Chlorothiazide/1'>Chlorothiazide</scene> is a semisynthetic chemical compound known chemically as 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (Figure 1) (reference). It has a chemical formula of C₇H₈ClN₃O₄S₂ and a molecular weight of 298 Da. This chemical compound consists of an aromatic ring, benzothiadiazine, a sulfonamide group, and a chloride. It has a melting point of 272 degrees Celsius, a flash point of 302.7 degrees Celsius, a solubility of 60 mg/ml in DMSO and less than 1 mg/ml in water, and appears as a white crystalline powder(reference). The structure was determined by X-Ray diffraction and was measured at a resolution of 2.1 Angstroms (reference). <scene name='75/756546/Drug/1'>Chlorothiazide was determined when bound to glutamate receptor 2</scene>. The enzyme cave of glutamate receptor 2 contained <scene name='75/756546/Inprogess/1'>specific amino acids</scene> that enabled binding of chlorothiazide. Binding involved hydrogen bonding between the nitrogen 12 and serine 242B, nitrogen 1 and serines 108B and 108E, and oxygen 17 and glycine 219 E (Figure 2 & 3).  Synthesis of chlorothiazide occurs through the reaction between 3-chloroaniline, chlorosulfonic acid, and ammonia; and it is catalyzed by formic acid (Figure 4)(reference).