Sandbox Reserved 1063: Difference between revisions

One of the two functional domains of AdcR is <scene name='69/694230/Dimerization_domain/3'> dimerization domain</scene>. This domain is made up of the <scene name='69/694230/Alpha_1/1'>α1 helix</scene>, the C-terminus of the <scene name='69/694230/Alpha_five/1'>α5 helix</scene> , and the <scene name='69/694230/Alpha_6/1'>α6 helix</scene>. This domain is connected to the DNA binding domain by the long α5 helix. The DNA binding domain stabilizes the major and minor groove of DNA via the winged helix-turn-helix motif. More importantly, the binding of zinc helps initiate the hydrogen bond network, which acts as an allosteric activator of AdcR to perform its biological function. The binding sites are found adjacent to the DNA binding domain.