Sandbox Reserved 1063: Difference between revisions

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[[Image:MarR_protein_family_slide.png|500px|left|thumb|'''Figure 1'''. Proteins MarR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3bpx (3BPX)], HucR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBK (2FBK)], TcaR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3KP5 (3KP5)], and OhrR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2pfb (2PFB)] are pictured above with conserved features of the MarR protein family highlighted]]

Contrasting with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1016~~/0307-4412(92)90039-O~~ </ref><ref> DOI: 10.1021/cr900077w</ref>. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria.

Contrasting with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1016 </ref><ref> DOI: 10.1021/cr900077w</ref>. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria.

==='''Structural Overview'''===

Sandbox Reserved 1063: Difference between revisions

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 [[Image:MarR_protein_family_slide.png|500px|left|thumb|'''Figure 1'''. Proteins MarR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3bpx (3BPX)], HucR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBK (2FBK)], TcaR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3KP5 (3KP5)], and OhrR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2pfb (2PFB)] are pictured above with conserved features of the MarR protein family highlighted]]
-Contrasting with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1016/0307-4412(92)90039-O </ref><ref> DOI: 10.1021/cr900077w</ref>. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria.
+Contrasting with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1016 </ref><ref> DOI: 10.1021/cr900077w</ref>. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria.
 ==='''Structural Overview'''===